Mitochondria: Masters of Epigenetics

Mitochondria: Masters of Epigenetics

Accumulating evidence argues that aging exerts a profound influence on epigenetics, and vice versa. A pair of studies by Merkwirth et al. and Tian et al. now provide insights on how mitochondrial stress experienced by C. elegans larvae propagates a specific and persistent epigenetic response that protects adult cells and extends lifespan.

Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress

BACKGROUND Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP production but also through metabolites generated in the tricarboxylic acid cycle, as well as ...

The Prospects of Epigenetics in Neuroscience

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Many turtle species are endangered through a variety of human activities, from beach development, boating and shipping, and fishing. Awareness of the problems has mostly focused on protection of beaches used for breeding as individuals return to highly specific sites where they are particularly vulnerable. Apart from their breeding sites, much less is known about their long and complex movement...

Toxicity of atorvastatin on isolated brain mitochondria

Background: Although the bio kinetics, metabolism and chemical toxicity of Atorvastatin are well known, until recently little attention was paid to the potential neurotoxic effect of Atorvastatin (Atv). Regarding the concrete evidences indicating Atv may reduce Coenzyme Q10 (CoQ10) levels through blockage of  metalonate cycle, the present work aims to determine if Atorvastatin may provide toxic...